Mazandaran Association of Emergency Medicine Humanistic Studies and Social Researches 3092-6467 2 1 2025 12 18 The Neuroscience of Gratitude: A Review of How Daily Practices Induce Neuroplasticity to Enhance Well-Being 236489 10.22034/hssr.2025.236489 EN Hanieh Abdolahzadeh Delkhosh Master of Science in General Psychology, Islamic Azad University, Tehran Science and Research Branch 0009-0003-9491-2755 Journal Article <strong><span style="font-size: 14.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: 'Times New Roman'; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; color: #0f1115; mso-font-kerning: 0pt; mso-ligatures: none;">Background:</span></strong><span style="font-size: 14.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: 'Times New Roman'; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; color: #0f1115; mso-font-kerning: 0pt; mso-ligatures: none;"> Gratitude, a positive emotional response to perceived benefits, has evolved from a philosophical concept to a subject of rigorous neuroscientific inquiry. Emerging evidence suggests deliberate gratitude practices can structurally and functionally remodel the brain.</span> <span style="font-size: 14.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: 'Times New Roman'; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; color: #0f1115; mso-font-kerning: 0pt; mso-ligatures: none;"><br><strong>Objective:</strong> This review synthesizes contemporary neuroimaging, psychophysiological, and behavioral research to examine the mechanisms by which gratitude practices induce neuroplastic changes that promote happiness and resilience.<br><strong>Methods:</strong> A narrative review of literature from 2000-2024 was conducted using PubMed, PsycINFO, and Google Scholar. Search terms included "gratitude neuroscience," "neuroplasticity AND gratitude," "gratitude intervention fMRI," and "gratitude well-being." Included studies employed fMRI, EEG, hormonal assays, or longitudinal intervention designs.<br><strong>Results:</strong> Neuroimaging studies consistently identify a gratitude network involving the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and ventral striatum. Longitudinal interventions (e.g., journaling, letters) demonstrate increased activity and connectivity within this network, coupled with reduced amygdala reactivity to threat. Psychophysiological data show downregulation of the HPA axis and increased vagal tone. Behavioral outcomes include sustained increases in subjective well-being, prosocial behavior, and resilience.<br><strong>Conclusion:</strong> Daily gratitude practice acts as a form of cognitive-emotional training that strengthens reward and social connection pathways via Hebbian plasticity. These practices may confer resilience by modulating stress-response systems. While promising, limitations include heterogeneous methodologies and a need for more longitudinal neuroimaging studies. Gratitude training presents a scalable, low-cost adjunct to clinical and wellness programs.</span> https://www.hssres.com/article_236489_5b251407e8038b9ff51ffbe17abd79e0.pdf